The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have activities in the field of life sciences.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

ICOA is also a member of:

and is a corresponding lab of French Alternative Energies and Atomic Energy Commission (CEA) LRC M09.

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Setting up a C18 column classification of web application:
This classification of C18 stationary phases is a simple map, in which each point corresponds to one column (more than 200 are checked). This map allows an easy comparison between these points (i.e. these columns), to show and understand the eventual changes in selectivity and retention from one to another column. The tools included in the software are able to select the phase by their mane, by the manufacturer’s name, by the ligand nature (C18, phenyl-hexyl, etc..) or by the particle type (fully or superficially porous silica). A tab “introduction” explain how get the better from this classification.

latest publications

Belaroussi, R. ; El Hakmaoui, A. ; Akssira, M. ; Guillaumet, G. ; Routier, S.
Regioselective Synthesis of 2,4-Substituted Pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyrimidines through Sequential Pd-Catalyzed Arylation and SNAr Reactions
Eur. J. Org. Chem. 2016, 3550-3558.

Plebanek, E. ; Chevrier, F. ; Roy, V. ; Garenne, T. ; Lecaille, F. ; Warszycki, D. ; Bojarski, A. J. ; Lalmanach, G. ; Agrofoglio, L. A.
Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S
Eur. J. Med. Chem. 2016, 121, 12-20.

Viault, G. ; Poupart, S. ; Mourlevat, S. ; Lagaraine, C. ; Devavry, S. ; Lefoulon, F. ; Bozon, V. ; Dufourny, L. ; Delagrange, P. ; Guillaumet, G. ; Suzenet, F.
Design, synthesis and biological evaluation of fluorescent ligands for MT1 and/or MT2 melatonin receptors
RSC Advances 2016, 6, 62508-62521.