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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

ICOA is also a member of:

and is a corresponding lab of French Alternative Energies and Atomic Energy Commission (CEA) LRC M09.

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Our last 3 publications

Elie, J. ; Vercouillie, J. ; Arlicot, N. ; Lemaire, L. ; Bidault, R. ; Bodard S. ; Hosselet, C. ; Deloye, J.-B. ; Chalon, S. ; Emond, P. ; Guilloteau, D. ; Buron, F. ; Routier, S.
Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer
J. Enzym. Inhib. Med. Chem. 2019, 34, 1-7.

Ejjoummany, A. ; Belaroussi, R. ; El Hakmaoui, A. ; Akssira, M. ; Guillaumet, G. ; Buron, F. ; Routier, S.
Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions
Molecules 2018, 23, 2740.

Faarasse, S. ; El Kazzouli, S. ; Suzenet, F. ; Guillaumet, G.
Palladium-catalyzed C3-arylations of 1H- and 2H-pyrazolo[4,3-b]pyridines on water
J. Org. Chem. 2018, 83, 12847–12854.

Our last 2 patents

  1. Yaacoub, K. ; Guillaudeux, T. ; Daniellou, R. ; Lafite, P. ; Aci-Sèche, S. ; Bonnet, P.
    Selective C-flip inhibitors as anticancer agents
  2. Patent N° Kind Date Application N° Date
    EP 3323428 A1 23 may 2018 EP 2016-306500 17 Nov 2016
    WO 2018091647 A1 24 may 2018 WO 2017-EP79575 17 Nov 2017

        Priority Application
                      EP 2016-306500 A 17 nov 2016
        ref. chem. Abstract : 2018:993556

  3. Routier, S. ; Suzenet, F. ; Chalon, S. ; Buron, F. ; Vercouillie, J. ; Melki, R. ; Boiaryna, L. ; Guilloteau, D. ; Pieri, L.
    Compounds for using in imagery and particularly for the diagnosis of neuro​degenerative diseases
  4. Patent N° Kind Date Application N° Date
    FR 3056592 A1 30 mar. 2018 FR 2016-59033 26 sep. 2016
    WO 2018055316 A1 29 mar. 2018 WO 2017-FR52592 26 sep. 2017

        Priority :
                      FR 2016-59033 A 26 sep. 2016
                      FR 2017-52001 A 10 mar. 2017
        ref. chem. Abstract : 168:387407