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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

ICOA is also a member of:

and is a corresponding lab of French Alternative Energies and Atomic Energy Commission (CEA) LRC M09.

Highlights

Congratulations to Celia SAPPEI (Research team Heterocycles, nucleosides and Imaging Agents) for obtaining Biotechnocentre award for best communication entitled "Synthesis & analysis of regiofunctionalized b-cyclodextrin derivatives by new pyridine carboxylate ligands towards MRI application".
Congratulations to Syntia Fayad (Analytical Team) to obtain the price CJSM 2016 the best scientific presentation entitled "Capillary electrophoresis coupled to high resolution mass spectrometry for the assessment of enzyme kinetics : Application to hyaluronidase".
Congratulations to Cedric Peyrot, from ICOA in close collaboration with the l'ENS-Rennes and GLYcoDiag, received the Award for the best poster presentation for his research on the chemo-enzymatic synthesis of glycolipids. Obtained via biocatalysis, these new bioactive hydrogels are tested as texturing agents for cosmetic applications.

Latest publications

Duval, J. ; Pecher, V. ; Poujol, M. ; Lesellier, E.
Research advances for the extraction, analysis and uses of anthraquinones: A review
Industrial Crops and Products 2016, 94, 812-833.

Chaikuad, A. ; Diharce, J. ; Schroder, M. ; Foucourt, A. ; Leblond, B. ; Casagrande, A. S. ; Desire, L. ; Bonnet, P. ; Knapp, S. ; Besson, T.
An unusual binding model of the methyl 9-anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) confers high selectivity for dual-specificity tyrosine phosphorylation-regulated kinases
J. Med. Chem. 2016, 59, 10315–10321.

Ortmayer, M. ; Lafite, P. ; Menon, B. R. ; Tralau, T. ; Fisher, K. ; Denkhaus, L. ; Scrutton, N. S. ; Rigby, S. E. ; Munro, A. W. ; Hay, S. ; Leys, D.
An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme
Nature 2016, 539, 593–597.