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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

ICOA is also a member of:

and is a corresponding lab of French Alternative Energies and Atomic Energy Commission (CEA) LRC M09.

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Our latest 3 publications

Kurdziel,M. ; Kopeć, M. ; Pâris, A. ; Lewiński, K. ; Lafite, P. ; Daniellou, R.
Thioglycoligation of aromatic thiols using a natural glucuronide donor
Org. Biomol. Chem. 2020, 18, 5582-5585.

Jismy, B. ; Tikad, A. ; Akssira, M. ; Guillaumet, G. ; Abarbri, M.
Efficient access to 3,5-disubstituted 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines involving SNAr and Suzuki cross-coupling reactions
Molecules 2020, 25, 2062.

Focsa, A. ; Iacob, A. ; Vasincu, I. ; Constantin, S. ; Andriescu, L. ; Sava, A. ; Buron, F. ; Routier, S. ; Apotrosoasei, M. ; Profire, L.
Optimization of the synthesis of diclofenac derivatives with hydrazone structure and in vitro evaluation of the anti-inflammatory potential
Revista de Chimie (Bucharest) 2020, 71, 305-314.

Our latest 2 patents

  1. Delhomel, J.-F. ; Perspicace, E. ; Majd, Z. ; Parroche, P. ; Walczak, R. ; Bonnet, P. ; Fogha, J.
    Preparation of piperazine and piperidine derivatives as ROR gamma modulators
    2. Patent N° Kind Date Application N° Date
    WO 2018138354 A1 2 aug 2018 WO 2018-EP52161 29 jan 2018
    CA 3050186 A1 2 Aug. 2018 CA 2018-3050186 29 Jan. 2018
    CN 110177775 A 27 Aug. 2019 CN2018-80007063 29 Jan. 2018
    AU 2018212616 A1 29 Aug. 2019 AU 2018-212616 29 Jan. 2018
    IL 268149 A 26 Sep. 2019 IL 2018-268149 29 Jan. 2018
    KR 2019112008 A 2 Oct. 2019 KR 2019-7024238 29 Jan. 2018
    EP 3573961 A1 4 Dec. 2019 EP 2018-701366 29 Jan. 2018
    JP 2020505413 T 20 Feb. 2020 JP 2019-541150 29 Jan. 2018
    US 20190358223 A1 28 Nov. 2019 US 2019-16481140 26 Jul. 2019
    IN 201917033668 A 4 Oct. 2019 IN 2019-17033668 21 Aug. 2019

        Priority Application :
                      EP 2017-305090 A 27 jan. 2017
                      WO 2018-EP52161 W 29 Jan. 2018
        ref. chem. Abstract : 2018:1420934

  2. Petoud, S. ; Eliseeva, S. ; Martinić, I. ; Placide, V. ; Suzenet, F. ; Delatouche, R. ; Leclerc, J. ; Foucault-Collet, A. ; Collet, G.
    Complexes of lanthanides based on functionalized PAMAM dendrimers
    3. Patent N° Kind Date Application N° Date
    WO 2018130542 A1 19 Jul. 2018 WO 2018-EP50510 10 Jan. 2018
    FR 3061714 A1 13 Jul. 2018 FR 2017-50245 11 Jan. 2017
    EP 3568401 A1 20 Nov. 2019 EP 2018-700278 10 Jan. 2018
    US 20190352511 A1 21 Nov. 2019 US 2019-16477103 10 Jul. 2019

        Priority Application
                      FR 2017-50245 A 11 Jan. 2017
                      WO 2018-EP50510 W 10 Jan. 2018
        ref. chem. Abstract : 2018:1336147