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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

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Latest productions

Our latest 3 publications

Chairat, A. ; Laurent, M. ; Routier, S. ; Buron, F. ; Bostyn, S.
Modeling temperature and species concentration profiles on a continuous-flow reactor applied to aldol condensation
ACS Omega 2022, 7, 19166–19175.

Avula, S. ; Peng, X. ; Lang, X. ; Tortorella, M. ; Josselin, B. ; Bach, S. ; Bourg, S. ; Bonnet, P. ; Buron, F. ; Ruchaud, S. ; Routier, S. ; Néagoie, C.
Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors
J. Enzym. Inhib. Med. Chem. 2022, 37, 1632-1650.

El Khamlichi, C. ; Reverchon, F. ; Hervouet-Coste, N. ; Robin, E. ; Chopin, N. ; Deau, E. ; Madouri, F. ; Guimpied, C. ; Colas, C. ; Menuet, A. ; Inoue, A. ; Bojarski, A. J. ; Guillaumet, G. ; Suzenet, F. ; Reiter, E. ; Morisset-Lopez, S.
Serodolin, a β-arrestin–biased ligand of 5-HT7 receptor, attenuates pain-related behaviors
PNAS 2022, 119, e2118847119.

Our latest 2 patents

  1. Daniellou, R. ; Lafite, P. ; Seničar, M. ; Roubinet, B. ; Landemarre, L.
    Néolectine spécifique et son utilisation pour détecter des microorganismes
    2. Patent N° Kind Date Application N° Date
    FR3116062 A1 13 may 2022 FR2011444 06 nov. 2020
    WO2022096829 A1 12 may 2022 WO2021-FR51944 04 nov. 2021

        Priority Application :
                      FR2011444 A 06 nov. 2020
        ref. chem. Abstract :

  2. Routier, S. ; Buron, F. ; Suzenet, F. ; Rodrigues, N. ; Chalon, S. ; Vercouillie, J. ; Guilloteau, D. ; Emond, P. ; Marzag, H.
    Radiolabelled compounds for diagnosing cholinergic neurodegenerative diseases
    3. Patent N° Kind Date Application N° Date
    WO2022106714 A1 27 may 2022 WO2021-EP82619 23 nov. 2021
    FR3116433 A1 27 may 2022 FR2020-12024 23 nov. 2020

        Priority Application :
                      FR2020-12024 23 nov. 2020
        ref. chem. Abstract : 2022:1369798