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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

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Our latest 3 publications

Villedieu-Percheron, E. ; Ferreira, V. ; Campos, J. F. ; Destandau, E. ; Pichon, C. ; Berteina-Raboin, S.
Quantitative determination of andrographolide and related compounds in andrographis paniculata extracts and biological evaluation of their anti-inflammatory activity
Book Chapter of The Benefits of Plant Extracts for Human Health, Edited by Charlampos Proetos Printed Edition of the Special Issue Published in Foods 2021, 129-140.

Zak, A. ; Marzag, H. ; Rodrigues, N. ; Vercouillie, J. ; Chalon, S. ; Buron, F. ; Routier, S.
Synthesis of γ-carboline N-oxide under gold(I)-catalysis and C-1 amino and fluoro γ-carboline
Tetrahedron 2021, 89, 132154.

Dagallier, C. ; Avry, F. ; Touchefeu, Y. ; Buron, F. ; Routier, S. ; Chérel, M. ; Arlicot, N.
Development of PET Radioligands Targeting COX-2 for Colorectal Cancer Staging, a Review of in vitro and Preclinical Imaging Studies
Frontiers in Medicine 2021, 8, 675209.

Our latest 2 patents

  1. Delhomel, J.-F. ; Perspicace, E. ; Majd, Z. ; Parroche, P. ; Walczak, R. ; Bonnet, P. ; Fogha, J.
    Preparation of pyrimidine derivatives as ROR gamma modulators
    2. Patent N° Kind Date Application N° Date
    WO 2018138356 A1 2 Aug. 2018 WO 2018-EP52163 29 Jan. 2018
    CA 3050045 A1 2 Aug. 2018 CA 2018-3050045 29 Jan. 2018
    CN 110177782 A 27 Aug. 2019 CN 2018-80007080 29 Jan. 2018
    AU 2018212618 A1 Aug 29, 2019 AU 2018-212618 29 Jan. 2018
    IL 268150 A 26 Sep. 2019 IL 2018-268150 29 Jan. 2018
    KR 2019112009 A 2 Oct. 2019 KR 2019-7024251 29 Jan. 2018
    EP 3573974 A1 4 Dec. 2019 EP 2018-701056 29 Jan. 2018
    JP 2020505412 T 20 Feb. 2020 JP 2019-541139 29 Jan. 2018
    BR 112019015399 A2 31 Mar. 2020 BR 2019-112019015399 29 Jan. 2018
    US 20190388414 A1 26 Dec. 2019 US 2019-16481172 26 Jul. 2019
    IN 201917033610 A 4 Oct. 2019 IN 2019-17033610 21 Aug. 2019
    ZA 2019005513 A 27 May 2020 ZA 2019-5513 21 Aug. 2019

        Priority Application :
                      EP 2017-305091 A 27 Jan. 2017
                      EP 2017-178889 A 29 Jun. 2017
                      WO 2018-EP52163 W 29 Jan. 2018
        ref. chem. Abstract : 2018:1420945

  2. Agrofoglio, L. A. ; Roy, V. ; Plebanek, E. ; Bessières, M.
    Preparation of benzimidazole derivatives for the treatment of filovirus and other infectious diseases
    3. Patent N° Kind Date Application N° Date
    EP 3296297 A1 21 Mar. 2018 EP 2016-306177 15 Sep. 2016
    WO 2018050771 A1 22 Mar. 2018 WO 2017-EP73185 14 Sep. 2017
    EP 3512838 A1 24 Jul. 2019 EP 2017-769033 14 Sep. 2017

        Priority Application
                      EP 2016-306177 A 15 Sep. 2016
                      WO 2017-EP73185 W 14 Sep. 2017
        ref. chem. Abstract : 2018:517227