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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

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Latest productions

Our latest 3 publications

Bournez, C. ; Gally, J.-M. ; Aci-Sèche, S. ; Bernard, P. ; Bonnet, P.
Virtual screening of natural products to enhance melanogenosis
Molecular Informatics 2024, e202300335.

Sanaa, H. ; Mimoun, L. ; Retailleau, P. ; Anselmi, E. ; Nicolas, C. ; Gillaizeau, I.
Cobalt-catalyzed annulation of benzimidates or NH-benzaldimines with ynamides: synthesis of 1-alkoxy- and 1-alkyl-3-aminoisoquinolines
Adv. Synth. Catal. 2024, 366, 2495-2500.

Frossard, N. ; Coïc, A. ; Saguet, T. ; Coïc, A. ; Himbert, F. ; Do Q.T. ; Galzi, J.-L. ; Suehs, C. ; Guillaumet, G. ; Bonnet, P. ; Bernard, P.
Randomized double-blind placebo-controlled cosmetic trial of a topical first-in-class Neutraligand targeting the chemokine TARC/CCL17 in mild-to-moderate atopic dermatitis
Int. J. Cosmet. Sci. 2024, 46, 468-477.

Our latest 2 patents

  1. Morisset-Lopez, S. ; Suzenet, F. ; Guillaumet, G. ; Deau, E. ; Robin, E. ; El Khamlichi, C. ; Reverchon-Assadi, F. ; Hervouet-Coste, N. ; Madouri, F. ; Hiebel, M.-A.
    Applications of biased ligands of the serotonin 5-HT7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation
  2. Patent N° Kind Date Application N° Date
    WO2022195102 A1 22 sept. 2022 WO2022-EP57227 18 mar. 2022
    CA3211341 A1 22 sept. 2022 CA2022-3211341 18 mar. 2022
    AU2022237901 A1 28 sep. 2023 AU2022-237901 18 mar. 2022

        Priority Application :
                      EP2021-315045 19 mar. 2021
                      WO2022-EP57227 18 mar. 2022
        ref. chem. Abstract : 180:185169

  3. Routier, S. ; Plé, K. ; Gay, M. ; Ben Jamaa, A. ; Chesné, C. ; Li, R. ; Martin, S. ; Daligaux, P.
    Cholic acid Fluorescent probes for in vivo/vitro identification and quantification of hepatic transporters
  4. Patent N° Kind Date Application N° Date
    US20220308043 A1 29 sep. 2022 US2022-17696315 16 mars 2022

        Priority Application :
                      US2021-63161595 16 mars 2021
        ref. chem. Abstract : 2022:2497259