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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

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Latest productions

Our latest 3 publications

Jouad, K. ; Eliseeva, S. ; Collet, G. ; Colas, C. ; Da Silva, D. ; Hiebel, M.-A. ; El Brahmi, N. ; Akssira, M. ; Petoud, S. ; El Kazzouli, S. ; Suzenet, F.
Near-Infrared Emitting Poly(amidoamine) Dendrimers with an anthraquinone core toward versatile non-invasive biological imaging
Biomolecules 2022, 23, 1392–1402.

Ostache, N.-C. ; Pâris, A. ; Hiebel, M.-A. ; Finaru, A.-L. ; Daniellou, R. ; Suzenet, F. ; Guillaumet, G.
Cytotoxic evaluation of original pyrazolo[3,4d]thiazoles and pyrazolo[3,4-c]pyrazoles
Farmacia 2022, 70, 258-265.

Zaki, M. ; Loubidi, M. ; Bilgiç, T. ; Birim, D. ; Akssira, M. ; Dagcı, T. ; Berteina-Raboin, S. ; Saso, L. ; Khouili, M. ; Armagan, G.
Design, synthesis, and Biological evaluation of novel tomentosin derivatives in NMDA-induced excitotoxicity
Pharmaceuticals 2022, 15, 421.

Our latest 2 patents

  1. Routier, S. ; Bénédetti, H. ; Vallée-Meheust, B. ; Bonnet, P. ; Plé, K. ; Aci-Sèche, S. ; Ruchaud, S. ; Braka, A. ; Champiré, A. ; Andrès, C. ; Vourc’h, P.
    4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine--(2H)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer
  2. Patent N° Kind Date Application N° Date
    EP3915990 A1 01 Dec. 2021 EP2020-305546 26 May 2020
    WO2021239727 A1 02 Dec. 2021 WO2021-EP63890 25 May 2021

        Priority Application:
                      EP2020-305546 A 26 may 2020
        ref. chem. Abstract : 2021:2607954

  3. Agrofoglio, L. A. ; Roy, V. ; De Schutter, C. ; Bessières, M. ; Gallardo, F.
    Preparation of antiviral acyclonucleoside analogs
  4. Patent N° Kind Date Application N° Date
    WO 2019206907 A1 31 Oct. 2019 WO 2019-EP60366 23 Apr. 2019
    CA 3097255 A1 31 Oct 2019 CA 2019-3097255 23 Apr. 2019
    EP3784680 A1 03 Mar. 2021 EP2019-720515 23 Apr. 2019
    US20210079031 A1 18 Mar. 2021 US2020-17050263 23 Oct. 2020

        Priority Application
                      EP 2018-305498 A 23 Apr. 2018
                      WO 2019-EP60366 W 23 Apr. 2019
        ref. chem. Abstract : 2019:2065299